Degens
The lower class living in the slums and older parts of the city, particularly those with obvious mutations and deformities.
Quote: "The discards and dregs of genetic engineering."
A wide variety of appearances.
Spider-Man 2099, Punisher 2099

Gene Dolls
Cloned women designed to be docile and of subpar intelligence.
They were used for cleaning and "personal service" in remote asteroid mining colonies.
Punisher 2099

Mutants
Standard Marvel mutants still exist in the world of 2099.
The remain feared and hated, but eventually are able to build their own sanctuary, Halo City. Like the 20th and early 21st centureis, there is a wide variety of appearances and powers in mutants.
X-Men 2099

Mutates Genetically designed undersea clones created by Alchemax to slave away in their underwater city New Atlantis.
The mutates later rebelled and attacked the surface world.
Spider-Man 2099 #43

Mutalocos
People who were physically transformed and driven mad by exposure to Necrotoxins.
Doom 2099 #43

Mutroids
People who were exposed to the toxic environment of Hellrock Island and subsequently developed substantial physical mutations including extra limbs, exaggerated musculature, and other deformities.
There exists a wide variety of mutations and abilities.
Colloquially known as "Troids."
Ravage 2099

Red Dogs
Genetically modified soldiers with red skin created by Alchemax. They were stronger, faster, and far more durable than normal soldiers.
Ultimately, the project was cancelled, and all the Red Dogs were hunted down and killed.
However, Alchemax was unaware the gene expression sometimes skips generations.
Punisher 2099 #5

Transhumans People who were genetically engineered to have the superhuman metagene factor.
This engineering can occur before birth, or by a tailored virus later in life.
By the year 2399, the majority of humankind had the metagene factor.
2099: Manifest Destiny